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Extraction recovery and matrix effect of osimertinib and IS in rat plasma.
| Analyte | Concentration (ng/mL) | Extraction Recovery (%) | |
|---|---|---|---|
| Mean ± SD | RSD | ||
| Osimertinib | 400 | 95.24 ± 3.01 | 3.16 |
| 20 | 96.14 ± 1.83 | 1.90 | |
| 2 | 84.31 ± 3.18 | 3.77 | |
| Sorafinib | 500 | 87.22 ± 4.23 | 4.85 |
