Table 4.

Stability of osimertinib in rat plasma under various storage conditions.

Storage Condition	Concentration (ng/L)	Mean ± SD	RSD%
Autosampler (4 °C) temperature for 24 h	2	2.12 ± 0.23	10.85
	20	21.45 ± 1.81	8.44
	400	406.81 ± 5.64	1.39
Room temperature (25 °C) for 24 h	2	2.21 ± 0.26	3.66
	20	22.45 ± 2.18	9.71
	400	407.28 ± 5.12	1.26
Storage temperature (−80 °C) for 30 days	2	2.29 ± 0.25	10.92
	20	21.33 ± 1.74	8.16
	400	406.34 ± 7.51	1.85
Three freeze–thaw cycles (each at −80 °C for 24 h)	2	2.27 ± 0.19	8.37
	20	22.20 ± 1.92	8.65
	400	406.17 ± 6.19	1.52