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Pharmacokinetic parameters of osimertinib after oral administration of 4.5 mg/kg to rats.
| Pharmacokinetic Parameter | Osimertinib |
|---|---|
| AUC(0–t), ng/mL·h | 382.00 ± 69.00 |
| AUC(0–∞), ng/mL·h | 426.01 ± 81.73 |
| MRT, h | 14.51 ± 1.91 |
| t1/2z, h | 14.96 ± 3.44 |
| tmax, h | 4.80 ± 1.10 |
| Cmax, ng/mL | 28.49 ± 3.97 |
| Vz/F, L/kg | 233.82 ± 66.68 |
| CLz/F, L/h/kg | 10.84 ± 1.94 |
Data are expressed as the mean ± SD (n = 7).
