Table IV.

Univariable and multivariable Cox regression analysis of the circRNA signature and survival of patients with non-functioning pituitary adenoma in the training, test group and entire group.

		Training set (n=37)				Test set (n=36)				Entire dataset (n=73)
			95% CI of HR				95% CI of HR				95% CI of HR
Variables	Comparison	HR	Lower	Upper	P-value	HR	Lower	Upper	P-value	HR	Lower	Upper	P-value
Univariable analysis
Signature	High-risk vs. low risk	2.36	1.59	3.51	<0.001	1.04	0.88	1.22	0.67	9.89	2.92	33.54	<0.001
Sex	Male vs. female	1.45	0.42	4.99	0.55	0.58	0.17	1.93	0.38	0.96	0.42	2.18	0.93
Age, years	>55 vs. ≤55	0.42	0.11	1.59	0.20	0.78	0.23	2.60	0.68	0.58	0.24	1.40	0.23
Knosp classification	I–II vs. III–IV	0.97	0.56	1.67	0.91	1.20	0.69	2.09	0.52	1.08	0.74	1.58	0.68
Multivariable analysis
Signature	High-risk vs. low risk	3.42	1.82	6.41	<0.001	1.08	0.88	1.33	0.45	10.07	2.92	34.77	<0.001
Sex	Male vs. female	0.40	0.03	4.69	0.47	0.50	0.13	1.84	0.29	0.80	0.34	1.87	0.61
Age, years	>55 vs. ≤55	3.79	0.52	27.75	0.19	0.94	0.27	3.30	0.92	0.80	0.32	2.01	0.64
Knosp classification	I–II vs. III–IV	1.77	0.66	4.79	0.26	1.29	0.71	2.37	0.40	1.14	0.75	1.73	0.54

CircRNA, circular RNA; HR, hazard ratio; CI, confidence interval.