Table 1.

Pooled relative sensitivity and specificity of high-risk human papillomavirus (hrHPV) assays based on signal amplification (SA) and polymerase chain reaction (PCR) on self samples versus clinician samples

Assay	Outcome	No of studies		Ratio (95% CI)
				Sensitivity	Specificity	Test positivity	PPV
SA	CIN2+	23		0.85 (0.80 to 0.89)*	0.96 (0.93 to 0.98)*	1.14 (1.05 to 1.24)	0.71 (0.62 to 0.82)
	CIN3+	9		0.86 (0.76 to 0.98)*	0.97 (0.95 to 0.99)*		0.65 (0.57 to 0.78)
PCR	CIN2+	17		0.99 (0.97 to 1.02)	0.98 (0.97 to 0.99)*	1.00 (0.94 to 1.06)	0.97 (0.90 to 1.04)
	CIN3+	8		0.99 (0.96 to 1.02)	0.98 (0.97 to 0.99)*		0.90 (0.78 to 1.05)

PPV=positive predictive value; CIN2+=cervical intraepithelial neoplasia of grade 2 or worse; CIN3+=cervical intraepithelial neoplasia of grade 3 or worse.

^*Statistically significantly different from unity.