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. 2018 Oct 30;41(1):246–256. doi: 10.3892/or.2018.6832

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Copyright: © Pan et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 4. — BPTF promotes glioma growth and invasion via Myc signaling. (A) The Gene-Cloud of Biotechnology (GCBI) database analysis revealed that Myc interacted with BPTF. (B) The COXPRESdb database analysis revealed that MYCBP2 was predicted to interact with BPTF. (C) The COXPRESdb database co-expression analysis revealed that BPTF and MYCBP2 expression had a positive linear correlation. (D) The Oncomine database analysis also revealed that BPTF and MYCBPAP expression had a positive correlation. (E) Real-time PCR revealed that c-Myc mRNA expression was upregulated in U251^BPTF-OE cells, but downregulated in U251^BPTF-KD cells. (F) Western blotting revealed that c-Myc protein expression was upregulated in U251^BPTF-OE cells, but downregulated in U251^BPTF-KD cells.

Figure 4. — BPTF promotes glioma growth and invasion via Myc signaling. (A) The Gene-Cloud of Biotechnology (GCBI) database analysis revealed that Myc interacted with BPTF. (B) The COXPRESdb database analysis revealed that MYCBP2 was predicted to interact with BPTF. (C) The COXPRESdb database co-expression analysis revealed that BPTF and MYCBP2 expression had a positive linear correlation. (D) The Oncomine database analysis also revealed that BPTF and MYCBPAP expression had a positive correlation. (E) Real-time PCR revealed that c-Myc mRNA expression was upregulated in U251^BPTF-OE cells, but downregulated in U251^BPTF-KD cells. (F) Western blotting revealed that c-Myc protein expression was upregulated in U251^BPTF-OE cells, but downregulated in U251^BPTF-KD cells.