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. 2018 Nov 27;9:2949. doi: 10.3389/fmicb.2018.02949

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Copyright © 2018 Saleh, Rüschenbaum, Welsch, Zeuzem, Moradpour, Gouttenoire and Lange.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The pro-viral effects of GSKβ are limited to HCV in comparison to HEV. No effects of GSK3 inhibition on HEV replication. Huh-7-derived cells (S10-3) harboring a selectable HEV replicon construct (HEV Kernow-C1 strain) were treated with 5 μM CHIR99021 for 48 h or transfected with siRNAs to silence GSK3α and β gene expression for 72 h. HEV RNA levels normalized to GAPDH mRNA are expressed relative to negative control siRNA-transfected cells. Data are presented as mean ± SEM of two experiments performed in triplicate and compared by Wilcoxon M Whitney U-test (n.s., not significant) with the control group.