FIGURE 5.

Biomodulatory treatment of AML cell lines in combination with midostaurin. (A) MV4-11 and (B) MOLM-13 cells were incubated in RPMI supplemented with 10% FCS and treated with single agent DMSO, ATRA, AZA, PGZ, MIDO or combinations thereof. On day 3 during treatment cells were counted by trypan blue staining. Data represent means of cell numbers from three independent experiments. Error bars indicate the standard deviation. Statistical analysis for group differences compared to DMSO were performed using Friedman and Dunn’s multiple comparisons test. ns p > 0.05, ^∗p ≤ 0.05, ^∗∗p ≤ 0.01, ^∗∗∗p ≤ 0.001, ^∗∗∗∗p ≤ 0.0001.