Table 1.
Growth inhibition of T47D, MCF7, HCT116 and Caco2 human cancer cell lines after 48 h exposure time. IC50 values are expressed as mean ± SD of three independent experiments.
| Code | T47D IC50 µM | MCF7 IC50 µM | HCT116 IC50 µM | Caco2 IC50 µM |
|---|---|---|---|---|
| 2 | >200 | >200 | >200 | >200 |
| 3 | 162 ± 9 | 168 ± 11 | 185 ± 11 | 188 ± 10 |
| 5a | 132 ± 6 | 128 ± 5 | 154 ± 8 | 145 ± 9 |
| 5b | 38 ± 2 | 33 ± 4 | 48 ± 4 | 42 ± 2 |
| 5c | 56 ± 7 | 61 ± 2 | 78 ± 9 | 68 ± 5 |
| 5d | 44 ± 6 | 42 ± 3 | 51 ± 4 | 53 ± 3 |
| 5e | 91 ± 8 | 88 ± 9 | 110 ± 6 | 103 ± 5 |
| 5f | 164 ± 13 | 173 ± 12 | 184 ± 18 | 166 ± 9 |
| 5g | 58 ± 8 | 55 ± 4 | 76 ± 5 | 72 ± 8 |
| 5h | 48 ± 4 | 49 ± 2 | 69 ± 8 | 62 ± 8 |
| 5i | 159 ± 9 | 168 ± 7 | 177 ± 11 | 182 ± 12 |
| 5j | 95 ± 3 | 99 ± 7 | 102 ± 13 | 98 ± 6 |
| 5k | 163 ± 10 | 160 ± 10 | 182 ± 17 | 178 ± 10 |
| 5l | 125 ± 14 | 138 ± 16 | 145 ± 15 | 159 ± 11 |
| 6a | >200 | >200 | >200 | >200 |
| 6b | 161 ± 8 | 172 ± 10 | 176 ± 18 | 178 ± 7 |
Reference compound, Doxorubicin, IC50 values range between 1–10 µM against the examined different cell lines.