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. 2018 Dec 4;5:180287. doi: 10.1038/sdata.2018.287

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Copyright © 2018, The Author(s)

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ The Creative Commons Public Domain Dedication waiver http://creativecommons.org/publicdomain/zero/1.0/ applies to the metadata files made available in this article.

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Principal component analysis (PCA) of (a) all sequenced samples (total 30 samples), (b) ribosome-free and (c) polysome-bound samples at D0, D1, D4, D9 and D15 (n = 3). RPKM values (polysome-bound) heatmap of (d) developmental markers showing mesoderm, cardiac mesoderm, endoderm and ectoderm genes expression; and (e) cardiac markers showing cardiomyocytes (CM), endothelial cells (EC) and smooth muscle cells (SMC) genes expression. (f) RNA-seq data validation of cardiac developmental marker gene expression using qPCR. Relative expression to hESC (D0) of pluripotency (POU5F1 and NANOG), mesoderm (T and EOMES) and cardiac markers (GATA4, NKX2-5 and TNNT2) on distinct days of cardiac differentiation using RNA-seq and q-PCR data. Values are expressed in log2 base.