Figure 3.

In vitro release of Apa-Gel.

Notes: Apa-Cyc was prepared to form a temperature-sensitive phase-change hydrogel (named Apa-Gel). Apa-Gel was incubated in ddH₂O at 37°C. The ddH₂O was collected at the indicated time points for LC-MS/MS experiments. (A) Results are shown as the drug-sustaining curve of Apa-Gel. (B–E) The typical photographs of Apa-Gel at (B) 0-hour time point, (C) 24-hour time point, (D) 96-hour time point, and (E) 408-hour time point.

Abbreviations: ACN, acetonitrile; Apa-Gel, a temperature-sensitive phase-change hydrogel of apatinib; ddH₂O, double-distilled H₂O; LC-MS/MS, liquid chromatograph mass spectrometry/mass spectrometry; MRM, multi reaction monitoring.