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. 2018 Nov 29;11:8529–8541. doi: 10.2147/OTT.S188209

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© 2018 Wang and Tang. This work is published and licensed by Dove Medical Press Limited

The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.

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In vivo release of apatinib formulations in HCC tumor tissues.

Notes: Apa-Gel, Apa-Sol, and Apa-Cyc were injected into subcutaneous tumor tissues formed by MHCC97-H cells. At the indicated time points, tumor tissues were harvested and apatinib sustaining in tumor tissues was extracted by ACN for LC-MS/MS examination. (A–D) Apatinib sustaining in HCC subcutaneous tumor tissues injected with Apa-Gel formed by MHCC97-H cells was examined at (A) 0-hour time point, (B) 24-hour time point, (C) 96-hour time point, and (D) 408-hour time point with LC-MS/MS. (E–G) Apatinib sustaining in HCC subcutaneous tumor tissues injected with Apa-Sol formed by MHCC97-H cells was examined at (E) 0-hour time point, (F) 24-hour time point, and (G) 96-hour time point with LC-MS/MS. (H–J) Apatinib sustaining in HCC subcutaneous tumor tissues injected with Apa-Cyc formed by MHCC97-H cells was examined at (H) 0-hour time point, (J) 24-hour time point, and (I) 96-hour time point with LC-MS/MS. (K) The sustaining curve of apatinib in subcutaneous tumor tissues formed by MHCC97-H cells is shown. *P<0.05 vs Apa-Gel group with Apa-Sol group; *P<0.05 vs Apa-Gel group with Apa-Cyc group.

Abbreviations: ACN, acetonitrile; Apa-Gel, a temperature-sensitive phase-change hydrogel of apatinib; Apa-Sol, apatinib solution; Apa-Cyc, apatinib–cyclodextrin inclusion complex; LC-MS/MS, liquid chromatography mass spectrometry/mass spectometry.

In vivo release of apatinib formulations in HCC tumor tissues.

Notes: Apa-Gel, Apa-Sol, and Apa-Cyc were injected into subcutaneous tumor tissues formed by MHCC97-H cells. At the indicated time points, tumor tissues were harvested and apatinib sustaining in tumor tissues was extracted by ACN for LC-MS/MS examination. (A–D) Apatinib sustaining in HCC subcutaneous tumor tissues injected with Apa-Gel formed by MHCC97-H cells was examined at (A) 0-hour time point, (B) 24-hour time point, (C) 96-hour time point, and (D) 408-hour time point with LC-MS/MS. (E–G) Apatinib sustaining in HCC subcutaneous tumor tissues injected with Apa-Sol formed by MHCC97-H cells was examined at (E) 0-hour time point, (F) 24-hour time point, and (G) 96-hour time point with LC-MS/MS. (H–J) Apatinib sustaining in HCC subcutaneous tumor tissues injected with Apa-Cyc formed by MHCC97-H cells was examined at (H) 0-hour time point, (J) 24-hour time point, and (I) 96-hour time point with LC-MS/MS. (K) The sustaining curve of apatinib in subcutaneous tumor tissues formed by MHCC97-H cells is shown. *P<0.05 vs Apa-Gel group with Apa-Sol group; *P<0.05 vs Apa-Gel group with Apa-Cyc group.

Abbreviations: ACN, acetonitrile; Apa-Gel, a temperature-sensitive phase-change hydrogel of apatinib; Apa-Sol, apatinib solution; Apa-Cyc, apatinib–cyclodextrin inclusion complex; LC-MS/MS, liquid chromatography mass spectrometry/mass spectometry.