Figure 5.

Long-acting antitumor effect of Apa-Gel formulations on the subcutaneous growth of MHCC97-H cells.

Notes: MHCC97-H cells were injected into nude mice to form subcutaneous tumors. The control group was the mice that received intratumor injection of solvent control. Mice were administered with one intratumor injection of Apa-Sol, Apa-Cyc, or Apa-Gel. The results are shown as (A) photographs of tumors, (B) tumor volumes, and (C) tumor weights. *P<0.05 vs Apa-Gel group with control group; *P<0.05 vs Apa-Gel group with Apa-Sol group; *P<0.05 vs Apa-Gel group with Apa-Cyc group.

Abbreviations: Apa-Gel, a temperature-sensitive phase-change hydrogel of apatinib; Apa-Sol, apatinib solution; Apa-Cyc, apatinib–cyclodextrin inclusion complex.