Table 3.

Univariate regression analyses for predicting the three outcomes of interest: acuity increase, deterioration event and length of stay

	Beta	CI	OR (CI)	P values
Acuity increase: univariate logistic regressions (n=292, e=84)
MR-proADM	0.24	−0.02 to 0.48	1.27 (1.02 to 1.62)	0.037
CRP	0.003	−0.0005 to 0.0063	1.00 (1.00 to 1.01)	0.088
WBC	0.04	−0.008 to 0.094	1.05 (1.00 to 1.10)	0.09
Gender	0.14	−0.38 to 0.65	1.15 (0.69 to 1.92)	0.684
Age	0.1	0.019 to 0.1925	1.11 (1.02 to 1.21)	0.023
Age2	−0.0008	−0.0016 to 0.0001	1.00 (0.99 to 1.00)
Other comorbidities	−0.32	−0.96 to 0.28	0.72 (0.38 to 1.32)	0.267
COPD/HF*	0.81	0.26 to 1.36	2.25 (1.30 to 3.91)	0.004
Deterioration event: univariate logistic regressions (n=292, e2=32)
MR-proADM	0.37	0.11 to 0.64	1.44 (1.12 to 1.90)	0.006
CRP	0.003	−0.002 to 0.01	1.00 (1.00 to 1.01)	0.255
WBC	0.02	−0.05 to 0.09	1.02 (0.95 to 1.10)	0.506
Gender	0.17	−0.57 to 0.92	1.19 (0.57 to 2.50)	0.648
Age	0.21	0.06 to 0.40	1.23 (1.06 to 1.49)	0.013
Age2	−0.002	−0.003 to 0.001	1.00 (1.00 to 1.00)
Other comorbidities	1.14	0.38 to 1.90	3.14 (1.47 to 6.69)	0.003
COPD/HF*	0.67	−0.14 to 1.46	1.96 (0.87 to 4.29)	0.095
Length of stay: simple linear regressions (n=292, e=84, e2=32)
MR-proADM	0.7	0.49 to 0.92	NA	<0.0001
CRP	0.05	−0.05 to 0.15	NA	0.368
WBC	−0.06	−0.38 to 0.27	NA	0.73
Gender	0.08	−0.04 to 0.20	NA	0.18
Age	0.007	0.004 to 0.010	NA	<0.0001
Other comorbidities	0.18	0.05 to 0.32	NA	0.009
COPD/HF*	0.07	−0.07 to 0.21	NA	0.318

The p values are for the statistical significance of the corresponding covariate in the related model. Analyses for the NEWS as a predictor are shown in Table 4.

*n=282, e=82, e2=29.

COPD, chronic obstructive pulmonary disease; CRP, C reactive protein; e, number of acuity increases; e2, number of deterioration events; HF, heart failure; MR-proADM, mid-regional pro-adrenomedullin; n, total number of cases; NA, not applicable; NEWS, National Early Warning Score; WBC, white blood cell.