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. 2018 Oct 1;35(12):2957–2970. doi: 10.1093/molbev/msy180

Fig. 3.

Fig. 3.

Trends in lipid-associated allele frequencies. (A) Probability that the trait-increasing allele is more common in African than European populations in the 1000 Genomes Project data (1000 Genomes Project Consortium 2015) for lipid-related traits. We show results for each trait with different P-value cutoffs. Vertical bars represent 95% confidence intervals. Inset shows the direction of effect for the derived FADS1 haplotype, using rs174546 as the tag SNP. (B) LDL score for 1,003 ancient individuals, classified according to ancestry, as a function of their age. LDL score is the proportion of significant LDL-associated variants at which the ancient individual carries the trait-increasing allele (Materials and Methods).