Figure 2.

Quantiles of polygenic risk scores plotted against effects on phenotypes. (A) Body mass index; (B) verbal-numerical reasoning; (C) alcohol intake; (D) risk-taking; (E) neuroticism; (F) tobacco use; (G) depression; (H) alcohol dependency; and (I) anxiety disorder. A regression is performed with phenotype as outcome and each 5% quantile separately, whereby the effect size of each quantile is compared to the central quantile as reference, such that each polygenic score in the quantile in question is coded 1 and each polygenic score in the reference quantile is coded 0. In each regression, the covariates used in the main analyses are included. OR, odds ratio.