Table 2.

Polygenic Risk Score by Sex Interaction and Main Effects of Sex on Target Phenotypes

Target Phenotype	PRSMβ	PRSFβ	pinteraction	t/z Score	Sexβ	psex	t/z Score
Body Mass Index	0.07	0.07	.03	−2.23	0.10	1.55 × 10−725	35.36
Verbal-Numerical Reasoning	−0.05	−0.07	.12	1.55	0.05	4.82 × 10−25	10.34
Alcohol Intake	0.03	0.04	.11	−1.62	−0.18	<2 × 10−285	−66.46
Risk-Taking	0.15	0.14	.26	1.13	0.81	<2 × 10−285	57.70
Neuroticism	0.03	0.03	.52	−0.64	−0.15	<2 × 10−285	−49.19
Tobacco Use	1.10	1.33	.57	−0.56	1.02	5.79 × 10−14	7.51
Depressive Disorders	0.45	0.27	.36	0.91	−1.07	2.55 × 10−116	−22.93
Alcohol Dependency	1.28	2.93	.36	−0.92	5.45	1.79 × 10−39	13.15
Anxiety Disorders	0.37	0.57	.37	−0.89	−1.62	1.69 × 10−28	−11.07
Bipolar Disorder	0.21	0.53	.29	−1.06	−1.79	1.73 × 10−26	−10.65
Schizophrenia	2.56	0.40	.29	1.06	4.35	.00071	3.39

Significance threshold set at p < 4.5 × 10⁻⁴.

PRS_M/F, prediction of polygenic risk score on target phenotype for males and females.