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. 2018 Nov 29;13:8063–8074. doi: 10.2147/IJN.S186881

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© 2018 Baldwin et al. This work is published and licensed by Dove Medical Press Limited

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In vitro characterization of NanoOlaparib reveals that the sustained release and efficacy profiles are comparable to those of free Olaparib.

Notes: Size of (A) empty nanoparticles as measured by dynamic light scattering and (B) NanoOlaparib, (inset) transmission electron micrograph of NanoOlaparib stained with 1.5% phospotungstic acid depicts particles with an approximate size of 70 nm. (C) The release of NanoOlaparib at 37°C indicates that 100% of NanoOlaparib is released within 8 days. (D) IC₅₀ values comparing the treatment efficacy of NanoOlaparib vs free Olaparib.