Table 1.
Overview of treatment doses and schedule for oral Olaparib, NanoOlaparib, and cisplatin
Group | Dosage | Schedule | Administration |
---|---|---|---|
Daily i.p. administration of NanoOlaparib | |||
No treatment (n=5) | N/A | N/A | N/A |
Vehicle (n=5) | 10 µL/g bodyweight | 5× weekly | i.p. |
Oral Olaparib (n=5) | 50 mg/kg | 5× weekly | Oral gavage |
NanoOlaparib (n=5) | 50 mg/kg (10 µL/g bodyweight) | 5× weekly | i.p. |
Cisplatin (n=5) | 3 mg/kg | 2× weekly | i.p. |
NanoOlaparib + cisplatin (n=5) | 50 mg/kg (10 µL/g bodyweight) + 3 mg/kg | 5× weekly + 2× weekly | i.p. |
Twice weekly i.p. administration of NanoOlaparib | |||
Vehicle (n=5) | 10 µL/g bodyweight | 2× weekly | i.p. |
Oral Olaparib (n=5) | 50 mg/kg | 2× weekly | Oral gavage |
NanoOlaparib (n=5) | 50 mg/kg (10 µL/g bodyweight) | 2× weekly | i.p. |
Cisplatin (n=5) | 3 mg/kg | 2× weekly | i.p. |
Oral Olaparib + cisplatin (n=5) | 50 mg/kg + 3 mg/kg | 2× weekly + 2× weekly | Oral gavage i.p. |
NanoOlaparib + cisplatin (n=5) | 50 mg/kg (10 µL/g bodyweight) + 3 mg/kg | 2× weekly + 2× weekly | i.p. |
NanoOlaparib (n=4) | 100 mg/kg | 2× weekly | i.p. |
Abbreviation: i.p., intraperitoneal.