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Olaparib and NanoOlaparib IC50 values for cell lines derived from genetically engineered mouse models of ovarian cancer
| Cell line | Genomic profile | Free Olaparib IC50 (μM) | NanoOlaparib IC50 (μM) |
|---|---|---|---|
| 4412 | K-rasLSL-G12D/+, Pten−/− | 2.49±1.81 | 2.15±1.70 |
| 404 | Brca2−/−, Tp53−/−, Pten−/− | 3.43±1.18 | 4.42±2.23 |
| 403 | Brca2−/−, Tp53−/−, Pten−/− | 10.94±5.82 | 10.38±5.02 |
| 4306 | K-rasLSL-G12D/+, Pten−/− | 19.57±17.17 | 20.31±18.40 |
Notes: Values are presented as mean ± SD; n=3.
