TABLE 2.
11C-MC1 Uptake in Monkey Organs and Percentage Blockade with Pharmacologic Doses of COX-1 and COX-2 Inhibitors
| Blockade (%)* |
|||||
| COX-1 |
COX-2 |
||||
| Organ | SUV10–90 min (n = 8) | PS13 (n = 1) | Aspirin (n = 1) | MC1 (n = 1) | Celecoxib (n = 1) |
| Brain | 1.22 ± 0.25 | 17 | 0 | 21 | 0 |
| Lungs | 0.22 ± 0.05 | 7 | 0 | 0 | 0 |
| Heart | 0.70 ± 0.11 | 7 | 0 | 0 | 0 |
| Liver | 9.10 ± 2.42 | 21 | 0 | 0 | 14 |
| Spleen | 0.63 ± 0.10 | 12 | 0 | 0 | 5 |
| Gastrointestinal tract | 1.10 ± 0.26 | 19 | 0 | 14 | 0 |
| Kidney cortex | 1.73 ± 0.36 | 16 | 5 | 16 | 22 |
| Kidney medulla | 1.91 ± 0.27 | 22 | 13 | 35 | 30 |
| Ovaries | 0.82 ± 0.23 | 12 | 12 | 38 | 46 |
*
Corrected by plasma parent radioactivity at 4 timepoints.