Table 2.
Disease presence and activity based on the consensus reference standard
| New diagnosis (n=133) | Suspected relapse (n=151) | Full cohort (n=284) | |
|---|---|---|---|
| Disease presence | |||
| Small bowel disease present | 111 (83%) | 122 (81%) | 233 (82%) |
| Colonic disease present | 77 (58%) | 52 (34%) | 129 (45%) |
| Isolated small bowel disease present | 56 (42%) | 85 (56%) | 141 (50%) |
| Isolated colonic disease present | 22 (17%) | 15 (10%) | 37 (13%) |
| Both small bowel and colonic disease present | 55 (41%) | 37 (25%) | 92 (32%) |
| Total number of patients with disease present | 133 (100%) | 137 (91%) | 270 (95%) |
| Median number of involved small bowel segments, median (IQR), maximum | 1 (1–1), 4 | 1 (1–1), 3 | 1 (1–1), 4 |
| Median number of involved colonic segments, median (IQR), maximum | 1 (0–3), 6 | 0 (0–1), 6 | 0 (0–2), 6 |
| Disease activity | |||
| Small bowel disease active | 104 (94%) | 105 (86%) | 209 (90%) |
| Colonic disease active | 76 (99%) | 50 (96%) | 126 (98%) |
| Total number of patients with disease active | 130 (98%) | 121 (88%) | 251 (93%) |
| Criteria for activity* | |||
| Ulceration at endoscopy | 71 (55%) | 26 (21%) | 97 (39%) |
| CRP >8 mg/L | 47 (36%) | 57 (47%) | 104 (41%) |
| Calprotectin >250 μg/g | 41 (32%) | 43 (36%) | 84 (33%) |
| Histological evidence of activity | 100 (77%) | 36 (30%) | 136 (54%) |
Data are n (%), unless otherwise specified. CRP=C-reactive protein.
*
Patients could meet more than one criteria for disease activity.