Table 4.
Sensitivity and specificity for disease presence and extent against the consensus reference standard according to patient cohort
|
New diagnosis group (n=133) |
Suspected relapse group (n=151) |
|||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Disease positive, disease negative* | Sensitivity |
Specificity |
Disease positive, disease negative* | Sensitivity |
Specificity |
|||||||||
| MRE | Ultrasound | Difference | MRE | Ultrasound | Difference | MRE | Ultrasound | Difference | MRE | Ultrasound | Difference | |||
| Small bowel disease extent† | 111, 22 | 77% (66 to 86) | 66% (54 to 77) | 11% (−2 to 24) | 98% (82 to 100) | 88% (64 to 97) | 10% (−5 to 24) | 122, 29 | 82% (72 to 89) | 74% (62 to 83) | 8% (−3 to 19) | 92% (74 to 98) | 75% (50 to 90) | 17% (−3 to 37) |
| Small bowel disease presence | 111, 22 | 96% (89 to 99) | 92% (82 to 96) | 4% (−1 to 10) | 99% (84 to 100) | 91% (65 to 98) | 8% (−5 to 21) | 122, 29 | 97% (91 to 99) | 92% (82 to 96) | 5% (0 to 11) | 94% (76 to 99) | 78% (50 to 92) | 16% (−4 to 36) |
| Colonic disease extent† | 77, 56 | 17% (9 to 30) | 9% (4 to 19) | 8% (−2 to 19) | 93% (82 to 98) | 92% (80 to 97) | 1% (−7 to 10) | 52, 99 | 31% (17 to 48) | 33% (19 to 51) | −2% (−22 to 17) | 93% (85 to 97) | 94% (86 to 97) | −1% (−7 to 5) |
| Colonic disease presence | 77, 56 | 47% (31 to 64) | 67% (49 to 81) | −20% (−39 to −1) | 96% (86 to 99) | 95% (84 to 98) | 1% (−5 to 7) | 52, 99 | 84% (67 to 94) | 80% (61 to 91) | 4% (−11 to 20) | 96% (88 to 98) | 95% (89 to 99) | −1% (−5 to 4) |
| Small bowel and colonic disease extent† | 133, 0 | 33% (22 to 46) | 20% (12 to 30) | 13% (1 to 26) | NA | NA | NA | 137, 14 | 56% (43 to 68) | 40% (28 to 52) | 16% (2 to 31) | 80% (42 to 96) | 61% (24 to 88) | 19% (−20 to 59) |
| Small bowel and colonic disease presence‡ | 133, 0 | 65% (52 to 76) | 66% (53 to 77) | −1% (−15 to 13) | NA | NA | NA | 137, 14 | 88% (79 to 93) | 76% (64 to 85) | 12% (2 to 22) | 80% (42 to 96) | 61% (23 to 89) | 19% (−20 to 59) |
Data are n or % (95% CI), unless otherwise specified. MRE=magnetic resonance enterography. NA=not applicable.
*
Disease positive and disease negative patients by consensus reference standard.
†
Agreement with reference standard for disease presence and segmental location.
‡
Agreement with reference standard for disease presence (patients with disease in the small bowel, colon or both).