Table 2.
Association between secretor MBL2 polymorphisms and disease-specific survival*
| White patients | African American patients | |||||
|---|---|---|---|---|---|---|
| Genotype | No. (%) | RR of death† (95 % CI) | P‡ | No. (%) | RR of death† (95 % CI) | P‡ |
| Promoter SNPs | ||||||
| L/H (mbl2_11; rs11003125) | ||||||
| C/C (L/L) | 215 (41.1) | 1.0 (referent) | 120 (71.4) | 1.0 (referent) | ||
| C/G (L/H) | 238 (45.5) | 0.94 (0.70 to 1.26) | .67 | 44 (26.2) | 1.02 (0.62 to 1.69) | .93 |
| G/G (H/H) | 70 (13.4) | 1.29 (0.86 to 1.92) | .22 | 4 (2.4) | 2.27 (0.70 to 7.41) | .14 |
| Y/X (mbl2_12; rs7096206) | ||||||
| G/G (Y/Y) | 329 (61.7) | 1.0 (referent) | 124 (73.4) | 1.0 (referent) | ||
| G/C (Y/X) | 180 (33.8) | 0.61 (0.46 to 0.82) | .001 | 41 (24.3) | 1.02 (0.63 to 1.66) | .96 |
| C/C (X/X) | 24 (4.5) | 0.62 (0.31 to 1.27) | .20 | 4 (2.3) | 2.76 (0.81 to 9.40) | .11 |
| G/C + C/C§ | 204 (38.3) | 0.61 (0.46 to 0.81) | .001 | 45 (26.6) | 1.11 (0.69 to 1.77) | .69 |
| Exon 1 SNPs | ||||||
| A/D (mbl2_03; rs5030737) | ||||||
| C/C (non-D/non-D) | 447 (85.0) | 1.0 (referent) | 160 (96.4) | 1.0 (referent) | ||
| C/T (non-D/D) | 75 (14.2) | 0.97 (0.68 to 1.40) | .89 | 6 (3.6) | 0.48 (0.11 to 1.98) | .30 |
| T/T (D/D) | 4 (0.8) | 3.32 (0.68 to 13.64) | .10 | 0 | – | – |
| A/B (mbl2_01; rs1800450) | ||||||
| G/G (non-B/non-B) | 391 (75.5) | 1.0 (referent) | 152 (91.6) | 1.0 (referent) | ||
| G/A (non-B/B) | 120 (23.2) | 0.86 (0.63 to 1.17) | .34 | 13 (7.8) | 1.63 (0.67 to 3.95) | .28 |
| A/A (B/B) | 7 (1.3) | 1.91 (0.60 to 6.07) | .28 | 1 (0.6) | – | – |
| A/C (mbl2_02; rs1800451) | ||||||
| G/G (non-C/non-C) | 479 (97.0) | 1.0 (referent) | 91 (57.2) | 1.0 (referent) | ||
| G/A (non-C/C) | 14 (2.8) | 1.09 (0.44 to 2.67) | .18 | 58 (36.5) | 0.84 (0.53 to 1.33) | .42 |
| A/A (C/C) | 1 (0.2) | – | – | 10 (6.3) | 1.09 (0.42 to 2.83) | .88 |
*
RR = risk ratio; CI = confidence interval; SNP = single-nucleotide polymorphism; – = insufficient data.
†
Risk ratio of lung cancer death was adjusted for sex, stage (III–IV versus I–II), age at diagnosis, current smoking status, and pack-years of smoking.
‡
A Cox proportional hazards test was used. All statistical tests were two-sided.
§
A dominant model was assumed.