Figure 6. Microarray analysis of genes important in regulating lipid homeostasis using mRNA isolated from glomeruli of patients with FSGS enrolled in NEPTUNE study.

Microarray analysis of the glomerular transcripts in patients with FSGS enrolled in the NEPTUNE study. Numbers reflect fold change in glomerular gene expression in patients with FSGS when compared to living donors. Genes that passed FDR correction (q≤0.05) for multiple testing were considered significantly regulated and highlighted in blue (decreased expression) or red (increased expression) background colors. Genes that are not expressed in glomeruli from patients with FSGS are highlighted in white color.

Gene abbreviations: ABCA1 – ATP-binding cassette subfamily A member 1; ABCG1 – ATP-binding cassette subfamily G member 1; ACACA – acetyl-CoA carboxylase alpha; ACOX1, ACOX2 – acyl-CoA oxidase 1 and 2, respectively; APOC3 – apolipoprotein C3; APOL1 – apolipoprotein L1; APOM – apolipoprotein M; CD36 – cluster of differentiation 36; CETP – cholesteryl ester transfer protein; CPT1A – carnitine palmitoyltransferase I; CYP1B1 – cytochrome P450 family 1 subfamily B member 1; FASN – fatty acid synthase; GPBAR1 – G protein-coupled bile acid receptor 1; HMGCR – HMG-CoA reductase; INSIG1 – insulin induced gene 1; LDLR – low density lipoprotein receptor; NPC1 and NPC2 – Niemann-Pick disease, intracellular cholesterol transporter type 1 and type 2, respectively; NR1H2 – nuclear receptor subfamily 1, group H, member 2; PLIN3 – perilipin 3; SCAP – sterol regulatory element-binding protein cleavage-activating protein; SCD – stearoyl-CoA desaturase 1; SOAT1 – sterol O-acetyltransferase 1; SREBF1 – sterol regulatory element binding transcription factor 1; SREBF2 – sterol regulatory element binding transcription factor 2.