Table 1.

Serology of ADR injected and Col4a3 knockout mice.

	FSGS				Alport syndrome
	CTRL	ADR	CD	ADR+CD	Col4a3+/+ NS	Col4a3+/+ CD	Col4a3−/− NS	Col4a3−/− CD
Cholesterol, mg/dL	92.7±2.7	113.2±14.7	89.8±0.3	120.3±13.0&	117.9±3.4	131.3±4.7	203.5±10.0***	145.5±7.6**
HDL mg/dL	51.7±22.4	98.2±17.1	57.0±10.4	112.0±12.3	129.8±6.7	137.0±6.1	162.8±6.7#	138.3±5.4*
LDL mg/dL	BDL	−5.0±3.7	BDL	−3.3±0.5	5.4±0.3	5.8±0.9	14.9±1.2#	10.0±2.0
Triglycerides mg/dL	46.7±15.5	83.0±8.6	54.0±5.0	58.3±3.8	61.6±2.9	63.0±2.8	81.6±6.6	98.3±17.0
VLDL mg/dL	12.0±2.0	15.4±1.9	11.0±1.1	11.7±0.9	14.6±1.4	16.0±1.4	13.7±1.0	19.8±3.5*

Data are mean ± SD. ADR – adriamycin; CD – 2-hydroxypropyl-β-cyclodextrin (HPβCD); CTRL – control; NS – normal saline solution; HDL – high density lipids, LDL – low density lipids; VLDL – very low density lipids; BDL – below detection level.

^*p<0.05

^**p<0.01, when comparing CD treated vs. non-treated

^#p<0.01

^***p<0.001, when comparing knockout vs. controls

^&p<0.05, when comparing ADR+CD vs. CD group.