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. 2012 Sep;23(Suppl 8):viii41–viii46. doi: 10.1093/annonc/mds262

Figure 3.

Figure 3

Examples of molecular interactions and signalling at the antigen-presenting cell/T-cell immune synapse that inhibit T-cell activation and contribute to negative regulation of the immune response. CTLA-4, cytotoxic T-lymphocyte-associated antigen-4; GITR, glucocorticoid-induced TNFR-related protein; HLA, human leukocyte antigen; ICOS, inducible T-cell costimulator; LAG-3, lymphocyte-activation gene-3; MHC-II, major histocompatibility complex class II; PD1, programmed death 1; PD-L1, programmed death ligand-1.