Figure 2.

Overall survival, progression-free survival, and failure-free survival. (A) Probability of overall survival by treatment arm (P=0.281). (B) Probability of progression-free survival by treatment arm (P=0.142). Progression-free survival was defined as no clinical evidence of progression or relapsed disease, or any therapy used to treat persistent, progressive, or relapsed disease including withdrawal of immunosuppressive therapy or donor lymphocyte infusion. (C) Probability of failure-free survival in the (C) sirolimus + prednisone (2-drug) arm and (D) control (3-drug) arm. Failure-free survival was defined by the absence of secondary immunosuppressive therapy for chronic graft-versus-host disease, non-relapse mortality, and recurrent or progressive malignancy during treatment. Note: the numbers shown are estimates at each time point for each endpoint. Siro/Pred: sirolimus + prednisone; NRM: non-relapse mortality; FFS: failure-free survival.