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. 2018 Jun 14;103(11):1899–1907. doi: 10.3324/haematol.2018.190157

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Figure 4. — Overall survival according to transformation of previously diagnosed low-grade lymphoma, morphological characteristics, BCL2 rearrangement status, and MYC partner (IG gene versus non-IG gene). (A) Patients with double-hit/triple-hit lymphoma (DH/THL) at transformation of previously diagnosed low-grade lymphoma had inferior overall survival (OS) compared with patients who had de novo DH/THL [hazard ratio (HR) 2.99, P=0.007)]. (B) DH/THL patients with high-grade morphological characteristics showed a tendency toward inferior OS compared with patients with large-cell morphological characteristics, but it was not statistically significant (HR 2.32, P=0.09). (C) DH/THL patients with BCL2 rearrangements [MYC/BCL2, MYC/BCL2/BCL6, and MYC/BCL2 (BCL6 unknown)], so-called DH-BCL2/TH, showed a non-significant tendency toward inferior OS compared with those who did not have BCL2 rearrangements (MYC/BCL6) (HR 2.44, P=0.16). (D) No association was observed between MYC partner (IG versus non-IG) and OS (P=0.99).