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Mutated genes and parallel clonal evolution. (A) Fifty-four genes were mutated in 79 newly diagnosed MM patients. KRAS, DIS3, NRAS, BRAF and TP53 mutations accounted for 42% of all the mutations. (B) MAX (right and up) and DIS3 (left and down) showed concomitant mutations within the same patient. The proximity between subclonal mutations enabled us to detect that variants were in different sequencing reads, indicating a possible parallel subclonal evolution.
