Table 5. Regions of activation associated with illness course* across the whole brain.
Faces > Scrambled | |||||
Negative Correlation w/ Course | |||||
R Middle/inferior frontal gyrus | 42 | 40 | 6 | 4.28 | 194 |
Bodies > Scrambled | |||||
Negative Correlation w/ Course | |||||
L mPFC, dACC, caudate, insula, putamen, thalamus | -8 | 34 | 22 | 4.63 | 1228 |
R mPFC, caudate, putamen | 6 | 34 | 22 | 4.12 | 385 |
L cerebellum | -42 | -64 | -30 | 4.42 | 204 |
R cerebellum | 34 | -68 | -34 | 4.33 | 164 |
Note
*Course is based on an item adapted from the Structured Interview of Anorexia and Bulimia. Individuals are asked to characterize the course of their disorder from the point at which they were first diagnosed with an eating disorder to the period in which they no longer were diagnosed with an eating disorder. Descriptions of four options for disease course were aided with graphic depictions (S1 Fig).
R = right hemisphere; L = left hemisphere; mPFC = medial prefrontal cortex; dACC = dorsal anterior cingulate cortex