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. 2017 Sep 11;113(13):1677–1687. doi: 10.1093/cvr/cvx188

Figure 7.

Figure 7

Tie2-Cre; Cxcr4f/f mice phenocopy Cxcl12-null mice. (A–C) Ventral view of latex dye-perfused AA arteries of E17.5 control (A, n > 5) and Tie2-Cre; Cxcr4f/f (B, C; n > 5) foetuses. Compared to the control, abnormal arteries presumed to be TIA and LVA (marked with ‘?’) are present in the Cxcr4-mutants. Additional aberrant arterial branches were found (indicated with arrowheads). LVAs originating from LSA are absent. RITA and LITA: right and left internal thoracic arteries. (D–F) Pulmonary arteries of control (D, n > 5) and Cxcr4-mutants (E, F, n > 5) were visualized by the blue latex dye. Aberrant proximal branching points and abnormal superfluous branches in Cxcr4-mutants are indicated by arrowheads and yellow dots, respectively. (G and H) Tail abnormalities in Cxcr4-mutant embryos at E12.5 (G) and E17.5 (H). More than a half of Cxcr4-mutants had some forms of tail defect (6/11), including curly, edemic and haemorrhagic tails. Scale bars: A–C and H, 1 mm; D–F, 500 μm; G, 250 μm.