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. 2018 Mar 20;114(8):1098–1114. doi: 10.1093/cvr/cvy069

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Published on behalf of the European Society of Cardiology. All rights reserved. © The Author(s) 2018. For permissions, please email: journals.permissions@oup.com.

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Changing plasticity of NkxCE-positive cells from embryonic development to adulthood. During cardiac development, multipotent NkxCE-positive cells are able to build cells of all lineages in the heart. In neonatal hearts few NkxCE-positive cells (cardiomyoblasts) are re-activated and were shown to be able to differentiate into cardiomyocytes and smooth muscle cells. However, MICs induced by MI in adult mouse hearts indeed exhibit a somewhat embryonic gene profile but do not fully revert back to an embryonic phenotype.