Table 1.

Seven novel associations identified through Asian and trans-ethnic meta-analysis on inflammatory bowel disease.

Chr	SNP	Position	Effect allele	Study	Effect allele frequency		Inflammatory bowel disease
		[hg19]				Controls	Cases	OR	p	p random	p Q
						[N]	[N]	[95% CI]
22	rs2072711	37 268 555	A	Korean	0.32	1 185	1 332	1.21	0.002
								[1.07–1.36]
[NCF4, CSF2RB]				East Asian	0.26	3 719	2 824	1.21	6.55 × 10–7
								[1.13–1.28]
				European	0.17	48 485	38 155	1.00	0.954
								[0.97–1.03]
				Combined1 †		4 904	4 156	1.21	5.07 × 10 –9**	5.07 × 10 –9**	0.97
								[1.13–1.29]
				Combined2‡		53 389	42 311	1.03	0.027	0.121	4.42 × 10–7
								[1.00–1.05]
16	rs12928665	10 971 474	A	Korean	0.43	1 185	1 332	0.86	0.008
[CIITA]								[0.75–0.97]
				East Asian	0.46	3 719	2 824	0.83	1.29 × 10–7
								[0.76–0.90]
				European	0.76	48 485	38 155	0.94	1.29 × 10–8
								[0.91–0.96]
				Combined1 †		4 904	4 156	0.84	3.93 × 10 –9**	3.93 × 10 –9**	0.61
								[0.79–0.89]
				Combined2 ‡		53 389	42 311	0.92	1.23 × 10 –13**	0.006	0.002
								[0.90–0.94]
11	rs2074023	2 325 581	A	Korean	0.20	1 185	1 332	0.88	0.061
[TSPAN32]								[0.74–1.01]
				East Asian	0.25	3 719	2 824	0.87	8.45 × 10–4
								[0.79–0.95]
				European	0.40	48 485	38 155	0.95	1.71 × 10–7
								[0.93–0.97]
				Combined1†		4 904	4 156	0.87	1.29 × 10–4	1.29 × 10–4	0.92
								[0.81–0.94]
				Combined2 ‡		53 389	42 311	0.94	1.05 × 10 –9**	0.005	0.09
								[0.92–0.96]
5	rs2624435	17 095 269	A	Korean	0.14	1 185	1 332	0.92	0.287
[MYO10, BASP1]								[0.76–1.08]
				East Asian	0.14	3 719	2 824	0.89	0.035
								[0.79–1.00]
				European	0.23	48 485	38 155	0.94	1.93 × 10–7
								[0.92–0.96]
				Combined1†		4 904	4 156	0.90	0.019	0.019	0.79
								[0.83–0.98]
				Combined2 ‡		53 389	42 311	0.94	1.80 × 10 –8**	1.80 × 10 –8**	0.62
								[0.92–0.96]
15	rs7170683	101 488 582	A	Korean	0.48	1 185	1 332	0.98	0.748
[LRRK1]								[0.87–1.09]
				East Asian	0.47	3 719	2 824	0.98	0.673
								[0.91–1.06]
				European	0.52	48 485	38 155	0.96	1.98 × 10–4
								[0.94–0.98]
				Combined1†		4 904	4 156	0.98	0.597	0.597	0.97
								[0.93–1.05]
				Combined2 ‡		53 389	42 311	0.97	2.11 × 10–4	2.11 × 10–4	0.81
								[0.95–0.98]
14	rs57275892	35 747 271	A	Korean	0.35	1 185	1 332	0.80	1.98 × 10–4
[PPP2R3C, KIAA0391, PSMA6, NFKBIA]								[0.69–0.92]
				East Asian	0.33	3 719	2 824	0.92	0.025
								[0.84–0.99]
				European	0.17	48 485	38 155	0.95	1.50 × 10–4
								[0.92–0.98]
				Combined1†		4 904	4 156	0.88	9.25 × 10–5	0.029	0.06
								[0.83–0.94]
				Combined2 ‡		53 389	42 311	0.94	5.55 × 10–7	0.013	0.02
								[0.92–0.96]
1	rs17371986	160 402 259	A	Korean	0.83	1 185	1 332	0.88
[VANGL2]								[0.73–1.02]	0.080
				East Asian	0.79	3 719	2 824	0.95	0.205
								[0.86–1.03]
				European	0.79	48 485	38 155	0.95	5.18 × 10–5
								[0.93–0.98]
				Combined1†		4 904	4 156	0.93	0.047	0.047	0.39
								[0.86–1.00]
				Combined2 ‡		53 ,389	42 311	0.95	8.27 × 10–6	8.27 × 10–6	0.55
								[0.93–0.97]

Chr	Crohn's disease					Ulcerative colitis
	Cases	OR	p	prandom	pQ	Cases	OR	p	prandom	pQ
	(N)	(95% CI)				[N]	[95% CI]
22	637	1.29	6.95 × 10–4			695	1.14	0.082
[NCF4, CSF2RB]		[1.11–1.49]					[0.98–1.31]
	1 690	1.26	2.17 × 10–7			1 134	1.15	0.009
		[1.17–1.35]					[1.04–1.26]
	20 550	0.96	0.008			17 647	1.05	0.008
		[0.92–0.99]					[1.01–1.08]
	2 327	1.27	6.01 × 10 -10**	6.01 × 10 -10**	0.83	1 829	1.15	0.002	0.002	0.89
		[1.18–1.37]					[1.05–1.25]
	22 877	1.00	0.986	0.218	1.31 × 10-10	19 476	1.06	3.20 × 10–4	0.017	0.15
		[0.97–1.03]					[1.03–1.09]
16	637	0.90	0.140			695	0.82	0.004
[CIITA]		[0.76–1.04]					[0.69–0.96]
	1 690	0.81	1.07 × 10–6			1 134	0.85	8.92 × 10–4
		[0.73–0.90]					[0.76–0.95]
	20 550	0.94	6.61 × 10–6			17 647	0.94	2.36 × 10–5
		[0.91–0.97]					[0.91–0.97]
	2 327	0.84	7.53 × 10–7	3.48 × 10–4	0.22	1 829	0.84	1.38 × 10–5	1.38 × 10–5	0.64
		[0.78–0.90]					[0.78–0.91]
	22 877	0.93	2.22 × 10 –9**	0.020	0.005	19 476	0.93	4.50 × 10 –8**	0.007	0.03
		[0.90–0.95]					[0.90–0.95]
11	637	0.82	0.026			695	0.93	0.361
[TSPAN32]		[0.65–0.99]					[0.77–1.09]
	1 690	0.87	0.004			1 134	0.88	0.017
		[0.77–0.96]					[0.77–0.98]
	20 550	0.95	1.04 × 10–5			17 647	0.94	1.73 × 10–5
		[0.92–0.97]					[0.92–0.97]
	2 327	0.86	2.94 × 10–4	2.94 × 10–4	0.58	1 829	0.89	0.013	0.013	0.56
		[0.79–0.93]					[0.81–0.98]
	22 877	0.94	4.18 × 10–7	0.012	0.07	19 476	0.94	1.44 × 10–6	1.44 × 10–6	0.41
		[0.92–0.96]					[0.92–0.96]
5	637	1.05	0.628			695	0.80	0.028
[MYO10, BASP1]		[0.86–1.24]					[0.61–1.00]
	1 690	0.90	0.099			1 134	0.89	0.093
		[0.78–1.02]					[0.74–1.03]
	20 550	0.96	0.003			17 647	0.93	3.64 × 10–6
		[0.93–0.99]					[0.91–0.96]
	2 327	0.94	0.262	0.525	0.19	1 829	0.86	0.008	0.008	0.42
		[0.85–1.04]					[0.76–0.96]
	22 877	0.96	0.001	0.001	0.41	19 476	0.93	2.80 × 10–7	0.005	0.26
		[0.93–0.98]					[0.90–0.96]
15	637	0.86	0.027			695	1.11	0.117
[LRRK1]		[0.72–0.99]					[0.98–1.25]
	1 690	0.93	0.073			1 134	1.08	0.097
		[0.84–1.01]					[0.99–1.18]
	20 550	0.94	4.97 × 10–7			17 647	0.98	0.212
		[0.92–0.96]					[0.96–1.01]
	2 327	0.91	0.007	0.007	0.34	1 829	1.09	0.024	0.024	0.76
		[0.84–0.97]					[1.01–1.18]
	22 877	0.94	1.99 × 10 –8**	1.99 × 10 –8**	0.39	19 476	0.99	0.608	0.345	0.04
		[0.92–0.96]					[0.97–1.02]
14	637	0.82	0.006			695	0.79	7.59 × 10–4
[PPP2R3C, KIAA0391, PSMA6, NFKBIA]		[0.67–0.96]					[0.65–0.93]
	1 690	0.89	0.014			1 134	0.96	0.399
		[0.81–0.98]					[0.86–1.06]
	20 550	0.93	4.89 × 10–6			17 647	0.98	0.355
		[0.90–0.96]					[0.95–1.02]
	2 327	0.87	4.34 × 10–4	7.98 × 10–4	0.30	1 829	0.90	0.008	0.167	0.03
		[0.81–0.94]					[0.82–0.97]
	22 877	0.92	2.38 × 10 –8**	3.91 × 10 –4	0.20	19 476	0.97	0.064	0.145	0.01
		[0.89–0.95]					[0.94–1.00]
1	637	0.83	0.046			695	0.92	0.341
[VANGL2]		[0.66–1.01]					[0.74–1.10]
	1 690	0.99	0.913			1 134	0.88	0.037
		[0.89–1.10]					[0.77–1.00]
	20 550	0.99	0.576			17 647	0.92	1.95 × 10–8
		[0.96–1.02]					[0.89–0.95]
	2 327	0.95	0.276	0.368	0.09	1 829	0.89	0.023	0.023	0.74
		[0.87–1.04]					[0.81–0.98]
	22 877	0.99	0.384	0.414	0.17	19 476	0.92	1.58 × 10 –9**	1.58 × 10 –9**	0.83
		[0.96–1.02]					[0.89–0.94]

Chr, chromosome; CI, confidence interval; OR, odds ratio; Position, chromosome position. Genome-wide significant results from the combined analysis are indicated in bold.

**Association results at the genome-wide significance level [p < 5.0 × 10^–8].

†Combined1: Korean+East Asian dataset.

‡Combined2: Korean+East Asian+European dataset.