Table 1.
Vascular function (pD2 and Emax values) in control and DHT rats.
| Relaxation | pD2 | Emax | ||
|---|---|---|---|---|
| Control | DHT | Control | DHT | |
| EDHF mediated | 6.96 ± 0.05 | 6.36 ± 0.09* | 86.5 ± 3.42 | 66.2 ± 5.75* |
| Cx37 inhibition | 6.42 ± 0.09⁁ | 5.71 ± 0.08*⁁ | 75.9 ± 4.01⁁ | 54.65 ± 4.83*⁁ |
| Cx40 inhibition | 6.84 ± 0.06 | 6.24 ± 0.07* | 86.1 ± 4.17 | 61.5 ± 3.81* |
| Cx43 inhibition | 5.98 ± 0.12⁁ | 6.22 ± 0.04 | 66.9 ± 3.80⁁ | 62.6 ± 2.43 |
| Levcromakalim induced | 6.18 ± 0.04 | 6.11 ± 0.03 | 98.8 ± 0.35 | 97.5 ± 0.38 |
Values are expressed as mean ± SEM of 12 mesenteric arterial rings from six rats in each group. pD2 is presented as negative logarithm of the molar concentration producing the half maximum response. Emax is presented as a percentage of PE relaxation.
*P < 0.05 compared to control.
⁁ P < 0.05 compared to EDHF-mediated relaxation in their respective control and DHT groups.