Table 3.
Incident Fracture Events, Accidental Falls, or a Composite of Either Events Associated With Antidepressant Monotherapy, Compared With Antipsychotic Monotherapy
| Outcomes | Total Sample (n = 6,644 users) | Antipsychotic Monotherapy (n = 1,964 users) | Antidepressant Monotherapy (n = 4,680 users) | ||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Number of Events | User-months | Rate per 1,000 User-months | Number of Events | User-months | Rate per 1,000 User-months | Hazard Ratio (95% CI) | Number of Events | User-months | Rate per 1,000 User-months | Hazard Ratio (95% CI) | |||
| Unadjusted | Adjusted* | Unadjusted | Adjusted* | ||||||||||
| Falls | 1,040 | 83,105 | 12.5 | 296 | 24,419 | 12.1 | 1.00 | 1.00 | 744 | 58,686 | 12.7 | 1.05 (0.91–1.20) | 1.12 (0.97–1.29) |
| Fractures | 529 | 87,206 | 6.1 | 136 | 25,629 | 5.3 | 1.00 | 1.00 | 393 | 61,577 | 6.4 | 1.20 (0.99–1.46) | 1.35 (1.10–1.66) |
| Falls or fractures | 1,287 | 80,578 | 16.0 | 355 | 23,745 | 14.9 | 1.00 | 1.00 | 932 | 56,833 | 16.4 | 1.10 (0.97–1.24) | 1.16 (1.02–1.32) |
Notes: CI = confidence interval.
*Adjusted covariates are listed in Table 1.