Figure 6.

Relationship between pfhrp2-deleted mutants and overall P. falciparum prevalence. (A) Scatterplot by province comparing the proportion of P. falciparum infections due to pfhrp2-deleted mutants and overall P. falciparum prevalence. Colors correspond to Kinshasa (blue), North Kivu (red), South Kivu (green), and other (gray) Provinces. (B) Modeling results showing the predicted decrease in probability of infection with the pfhrp2-deleted strain only, as a function of prevalence in 0–5 year olds. The underlying strain frequency is held at a constant frequency in this example. Results are shown for a simple model assuming homogeneous force of infection throughout the population, and a more complex model allowing for variation in biting rate between individuals (see Supplementary Material).