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Schematic of a donor-specific cell-based platform for predicting individual radiosensitivity. Induced pluripotent stem cells obtained through the reprogramming of somatic cells from an individual can be differentiated into various cell types. Different cell types from the same individual can then be exposed to radiation for measurement of cellular responses in vitro using multiple biomarkers. iPSCs, induced pluripotent stem cells; RT, radiation; DNA DSBs, DNA double-strand breaks.
