. 2018 Dec 4;13(12):e0208547. doi: 10.1371/journal.pone.0208547

Table 2. Stratified COX proportional hazards model for overall survival.

	Colorectal cancer			Right-sided colorectal cancer			Left-sided colorectal cancer
	HR	95% CI	P-value^a	HR	95% CI	P-value^a	HR	95% CI	P-value^a
Pathological grade (grade 1–2 (reference^b))	1.26	1.04–1.52	0.018	1.47	1.06–2.05	0.022
Treatment
Chemotherapy only	Reference^b						Reference^b
Cetuximab plus chemotherapy	0.82	0.68–0.99	0.042				0.64	0.46–0.89	0.008
Bevacizumab plus chemotherapy	0.82	0.68–0.99	0.042				0.81	0.61–1.09	0.166
Sidedness (RSCC (reference^b))	0.75	0.62–0.91	0.003
NLR (≤ 3 (reference^b))	1.44	1.20–1.73	<0.001				1.53	1.23–1.90	<0.001
CA199 (≤ 37 U/ml (reference^b))	1.43	1.19–1.72	<0.001	1.96	1.41–2.73	<0.001	1.28	1.03–1.61	0.030
LDH (≤ 250 U/l (reference^b))	2.09	1.70–2.57	<0.001	2.04	1.42–2.94	<0.001	2.48	1.95–3.15	<0.001
CRP (≤ 3 mg/l (reference^b))	1.29	1.06–1.58	0.012	1.83	1.28–2.62	0.001

^a P-values were calculated using the Cox-proportional hazard model.

^b Defining this group as reference to calculate HR value.

HR, hazards ratio; 95% CI, 95% confidence interval; NLR, the neutrophil-to-lymphocyte ratio; PLR, the platelet-lymphocyte ratio; CEA, carcinoembryonic antigen; CA 19–9, carbohydrate antigen 19–9; LDH, lactate dehydrogenase; CRP, C-reactive protein.