Table 4.
Association of reported osteoarthritis (OA) and OA symptom severity to perceived memory loss (N = 719 with and 21,263 without history of memory loss) in Appalachian adults age 40 years or older: Influence of sleep and mood impairment
| Reported History of Memory Loss* |
Adjusted for Demographics†, Lifestyle Factors‡, BMI, Reproductive/Medical History*, and Sleep Impairment |
Adjusted for Demographics†, Lifestyle Factors‡, BMI, Reproductive/Medical History*, and Mood Disturbance |
Adjusted for Demographics†, Lifestyle Factors‡, BMI, Reproductive/Medical History§, Sleep Impairment, and Mood Disturbance |
|||||
|---|---|---|---|---|---|---|---|---|
| N | Yes | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Osteoarthritis | ||||||||
| No | 19,004 | 500 | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | |||
| Yes | 2,259 | 219 | 1.96 (1.62–2.39) | <0.00001 | 2.13 (1.74–2.80) | <0.00001 | 1.76 (1.43– 2.16) | <0.00001 |
| OA joint pain severity | ||||||||
| No OA | 19,004 | 500 | 1.00 (referent) | 1.00 (referent) | 1.00 (referent) | |||
| OA with joint pain never/rarely | 208 | 10 | 1.80 (0.92–3.52) | 0.09 | 1.87 (0.96–3.65) | 0.07 | 1.86 (0.93–3.70) | 0.08 |
| OA with joint pain sometimes | 693 | 35 | 1.42 (0.98–2.06) | 0.06 | 1.61 (1.11–2.35) | 0.01 | 1.53 (1.05–2.22) | 0.03 |
| OA with frequent joint pain | 1,385 | 174 | 2.18 (1.76–2.70) | <0.00001 | 2.34 (1.87–2.93) | <0.00001 | 1.83 (1.45–2.29) | <0.00001 |
| Test for trend | – | – | – | <0.00001 | – | <0.00001 | – | <0.00001 |
BMI = body mass index; CI = confidence interval; OA = osteoarthritis; OR = odds ratio.
Defined as a participant report of frequent short- or long-term memory loss.
Includes age, sex, race/ethnicity, years of education, annual household income, marital status, and employment status/disability.
Smoking (never, former, current); current alcohol consumption (yes/no); exercise (regular exercise program [yes/no]).
Includes reported physician diagnosis of comorbid conditions (heart, kidney, liver, immune, connective tissue, and thyroid disease, hypertension, dyslipidemia, diabetes, chronic obstructive pulmonary disease, or asthma) and use of antihypertensive, lipid-lowering, and other prescription medications; menopausal status and use of hormone replacement therapy.