Figure 6.
Association of high immune checkpoint expression with the presence of immune cell infiltrates. (A) Strong positive correlation of PD-L1 expression with the immune variables in the central immune signature (CIS, yellow box). 60% of the correlations were significantly positive, 3% were significantly negative (white crosses, FDR< 5%). (B) Very strong positive correlation of PD-1 expression with the immune variables in the central immune signature (CIS, yellow box). 69% of the correlations were significantly positive, 6% were significantly negative (white crosses, FDR< 5%). The abundance of cell populations was estimated by MCP-counter1 and CIBERSORT2.