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. 2018 Sep 6;7(12):e1500108. doi: 10.1080/2162402X.2018.1500108

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© 2018 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivatives License (http://creativecommons.org/licenses/by-nc-nd/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited, and is not altered, transformed, or built upon in any way.

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Figure 5. — Dexamethasone alone or combined with anti-PD-1 therapy significantly alters peripheral T cell compartments in mice bearing intracranial glioma tumors. (A) Timeline of blood draws relative to treatment schedule in the intracranial GL261-Luc experiment (N = 80, 10 mice/group): Blood was collected from the retro-orbital venous plexus of each mouse on days 19 and 27. Depicted are absolute numbers of (B) CD4+, (C) CD8+, (D) CD4+ FOXP3+ regulatory T cells (Treg), and (E) CD8/Treg ratios in peripheral blood by treatment group. Dexamethasone treatment, either alone or in combination with anti-PD-1 therapy, resulted in persistent reductions within CD4+, CD8+, and Treg compartments. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001. If no asterisks are shown, statistical analyzes yielded non-significant P-values.