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. 2018 Dec 3;150(12):1758–1768. doi: 10.1085/jgp.201711804

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© 2018 Michalski et al.

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Figure 7. — Single-channel recordings of hPanx1 at +120 mV. (A and B) Representative single-channel traces of WT hPanx1 (A; n = 10) and hPanx1+GS (B; n = 6). Outside-out patches were held at +120 mV. Highlighted gray box indicates the location of the inset underneath each respective recording. (C and D) Pooled all-amplitudes histogram generated from WT hPanx1 (C) and hPanx1+GS (D) at +120mV. Histograms were generated from four separate recordings for each channel. Black lines represent the closed population estimated by fitting a Gaussian function. (E and F) Representative traces of WT hPanx1 (E) and hPanx1+GS (F) showing reversible channel activity at +120 mV. CBX (100 µM) was applied using a rapid solution exchanger for the indicated period (red box).