Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2018 Dec 3;150(12):1606–1639. doi: 10.1085/jgp.201812203

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2018 Harris

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Figure 7. — Flexibility of residue side chains lining the connexin pore. Cutaway of Cx26 hemichannel color-coded by per-side-chain RMSF values obtained from umbrella sampling Hamiltonian replica exchange molecular dynamics. Three of the connexin subunits are removed so that the pore can be seen. The cytoplasmic end of the hemichannel is at the top. Most of the residues lining the pore have high RMSF values; in contrast, the ASP46 residue, which corresponds to the peak of the PMF for an impermeant molecule, is relatively rigid (from Luo et al. [2016]). Fig. 7 is reprinted with permission from Biophysical Journal.