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. 2018 Dec 3;217(12):4155–4163. doi: 10.1083/jcb.201711182

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© 2018 Shigematsu et al.

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Figure 4. — Structural model of microtubule binding of MAP4 and kinesin inhibition by MAP4. MAP4 is bound to the microtubule through the anchor point around the interdimer interface and through the weak binding site around the intradimer interface. Kinesin-1 competes against MAP4 for the weak binding site and finally eliminates MAP4 from the weak binding site. MAP4 is still anchored at the anchor point, and the rest of the regions may fold and accumulate above the interdimer interface.