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. 2018 Dec 3;215(12):3180–3193. doi: 10.1084/jem.20181211

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© 2018 Zhang et al.

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Figure 1. — VHL deficiency attenuates papain-induced lung inflammation. (A) Representative H&E staining of lung sections of control and Vhl^fl/fl LysM-Cre mice challenged with PBS or papain. Bar, 200 µm. (B) Perivascular and peribronchial inflammation scored from stained lung sections. (C and D) Concentrations of IL-5 and IL-13 in the BAL fluid. (E) Flow cytometry of CD45⁺ cells in BAL fluid and lungs. BALF, BAL fluid. (F–H) Absolute numbers of CD11b⁺ CD11c⁻ SiglecF⁺ eosinophils (EOS), CD11b⁺ Ly6C⁻ Ly6G⁺ neutrophils (NEU), and total CD45⁺ leukocytes in the BAL fluid. *, P < 0.05 (Student’s t test). Data are from one experiment representative of three independent experiments (mean and SEM of three to six mice per group).