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. 2018 Dec 3;215(12):3180–3193. doi: 10.1084/jem.20181211

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© 2018 Zhang et al.

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Figure 2. — Vhl^fl/fl LysM-Cre mice are protected from bleomycin-induced pulmonary fibrosis. (A) Lung sections of control and Vhl^fl/fl LysM-Cre mice challenged with PBS or bleomycin (5 mg/kg), stained with α-SMA (top) or Masson's blue (bottom). Bar, 200 µm. (B and C) Fibrosis and perivascular and peribronchial inflammation scored from stained lung sections. (D and E) Concentrations of TGFβ1 and IL-13 in the BAL fluid. (F and G) Concentration of IL-5 in the BAL fluid on days 14 and 7. *, P < 0.05; **, P < 0.01 (Student’s t test). Data are from one experiment representative of three independent experiments (mean and SEM of three to six mice per group).