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. 2018 Dec 3;215(12):3180–3193. doi: 10.1084/jem.20181211

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© 2018 Zhang et al.

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Figure 8. — HIF1α deficiency restores pulmonary fibrosis in Vhl^fl/fl LysM-Cre mice. (A) Representative H&E staining of lung sections of control, Vhl^fl/fl LysM-Cre, and Vhl^fl/fl Hif1a^fl/fl LysM-Cre mice challenged with PBS or 5 mg/kg bleomycin. Bar, 200 µm. (B) Fibrosis scored from stained lung sections. (C) Concentrations of TGFβ1 in the BAL fluid. (D and E) Absolute numbers of eosinophils and lung ILC2s. *, P < 0.05; **, P < 0.01; ***, P < 0.001 (Student’s t test). Data are from one experiment representative of three independent experiments (mean and SEM of three to six mice per group).