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. 2018 Dec 3;215(12):3136–3150. doi: 10.1084/jem.20181031

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© 2018 Chen et al.

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Figure 3. — CNBP negatively regulates IL-10. (A and B) Analysis of IL-10 by qRT-PCR (A) and ELISA (B) in Cnbp WT or KO BMDMs left unstimulated or stimulated with LPS. (C) qRT-PCR analysis of IL-10 mRNA in Cnbp WT or KO BMDMs left unstimulated or stimulated with LPS at different time courses. (D and E) WT and Cnbp^−/− macrophages were incubated with anti–IL-10R blocking antibody (D) or anti–IL-10 neutralizing antibody (E) before LPS stimulation, and IL-12β mRNA expression levels were determined by qPCR. Error bars represent SD of triplicate technical replicates. All data are representative of three independent experiments with similar results. **, P < 0.01; ***, P < 0.001.