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. 2018 Dec 3;215(12):2955–2958. doi: 10.1084/jem.20182042

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© 2018 Ransohoff

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms/). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 International license, as described at https://creativecommons.org/licenses/by-nc-sa/4.0/).

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graphic file with name JEM_20182042_Fig1.jpg — Use of animal models across the process of drug development. The cartoon indicates selected stages of drug development for which animal models may be applied. ADME: Absorption, Distribution, Metabolism, and Excretion.